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phenobarbital will minimize the level or impact of ramelteon by affecting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Significance Unidentified.phenobarbital will lessen the level or outcome of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Double brexpiprazole dose more than 1-two m